/***************************************************************************** closestMain.cpp (c) 2009 - Aaron Quinlan Hall Laboratory Department of Biochemistry and Molecular Genetics University of Virginia aaronquinlan@gmail.com Licenced under the GNU General Public License 2.0 license. ******************************************************************************/ #include "closestBed.h" #include "version.h" using namespace std; // define our program name #define PROGRAM_NAME "closestBed" // define our parameter checking macro #define PARAMETER_CHECK(param, paramLen, actualLen) (strncmp(argv[i], param, min(actualLen, paramLen))== 0) && (actualLen == paramLen) // function declarations void ShowHelp(void); int main(int argc, char* argv[]) { // our configuration variables bool showHelp = false; // input files string bedAFile; string bedBFile; string tieMode = "all"; bool haveBedA = false; bool haveBedB = false; bool haveTieMode = false; bool forceStrand = false; bool reportDistance = false; // check to see if we should print out some help if(argc <= 1) showHelp = true; for(int i = 1; i < argc; i++) { int parameterLength = (int)strlen(argv[i]); if( (PARAMETER_CHECK("-h", 2, parameterLength)) || (PARAMETER_CHECK("--help", 5, parameterLength))) { showHelp = true; } } if(showHelp) ShowHelp(); // do some parsing (all of these parameters require 2 strings) for(int i = 1; i < argc; i++) { int parameterLength = (int)strlen(argv[i]); if(PARAMETER_CHECK("-a", 2, parameterLength)) { if ((i+1) < argc) { haveBedA = true; bedAFile = argv[i + 1]; i++; } } else if(PARAMETER_CHECK("-b", 2, parameterLength)) { if ((i+1) < argc) { haveBedB = true; bedBFile = argv[i + 1]; i++; } } else if (PARAMETER_CHECK("-s", 2, parameterLength)) { forceStrand = true; } else if (PARAMETER_CHECK("-d", 2, parameterLength)) { reportDistance = true; } else if (PARAMETER_CHECK("-t", 2, parameterLength)) { if ((i+1) < argc) { haveTieMode = true; tieMode = argv[i + 1]; i++; } } } // make sure we have both input files if (!haveBedA || !haveBedB) { cerr << endl << "*****" << endl << "*****ERROR: Need -a and -b files. " << endl << "*****" << endl; showHelp = true; } if (haveTieMode && (tieMode != "all") && (tieMode != "first") && (tieMode != "last")) { cerr << endl << "*****" << endl << "*****ERROR: Request \"all\" or \"first\" or \"last\" for Tie Mode (-t)" << endl << "*****" << endl; showHelp = true; } if (!showHelp) { BedClosest *bc = new BedClosest(bedAFile, bedBFile, forceStrand, tieMode, reportDistance); delete bc; return 0; } else { ShowHelp(); } } void ShowHelp(void) { cerr << endl << "Program: " << PROGRAM_NAME << " (v" << VERSION << ")" << endl; cerr << "Authors: Aaron Quinlan (aaronquinlan@gmail.com)" << endl; cerr << "\t Erik Arner, Riken" << endl << endl; cerr << "Summary: For each feature in A, finds the closest " << endl; cerr << "\t feature (upstream or downstream) in B." << endl << endl; cerr << "Usage: " << PROGRAM_NAME << " [OPTIONS] -a -b " << endl << endl; cerr << "Options: " << endl; cerr << "\t-s\t" << "Force strandedness. That is, find the closest feature in B" << endl; cerr << "\t\tthat overlaps A on the same strand." << endl; cerr << "\t\t- By default, overlaps are reported without respect to strand." << endl << endl; cerr << "\t-d\t" << "In addition to the closest feature in B, " << endl; cerr << "\t\treport its distance to A as an extra column." << endl; cerr << "\t\t- The reported distance for overlapping features will be 0." << endl << endl; cerr << "\t-t\t" << "How ties for closest feature are handled. This occurs when two" << endl; cerr << "\t\tfeatures in B have exactly the same overlap with A." << endl; cerr << "\t\tBy default, all such features in B are reported." << endl; cerr << "\t\tHere are all the options:" << endl; cerr << "\t\t- \"all\" Report all ties (default)." << endl; cerr << "\t\t- \"first\" Report the first tie that occurred in the B file." << endl; cerr << "\t\t- \"last\" Report the last tie that occurred in the B file." << endl << endl; cerr << "Notes: " << endl; cerr << "\tReports \"none\" for chrom and \"-1\" for all other fields when a feature" << endl; cerr << "\tis not found in B on the same chromosome as the feature in A." << endl; cerr << "\tE.g. none\t-1\t-1" << endl << endl; // end the program here exit(1); }